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Targeted Allele Detail
Symbol: Bin1tm1Gcp
Name: bridging integrator 1; targeted mutation 1, George C Prendergast
MGI ID: MGI:2664484
Synonyms: Bin1-
Gene: Bin1  Location: Chr18:32377217-32435736 bp, + strand  Genetic Position: Chr18, 18.01 cM
Germline Transmission:  Earliest citation of germline transmission: J:83753
Parent Cell Line:  IT2 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacing the region encoding the BAR domain (part of exon 3 and all of exons 4 and 5) with a neomycin resistance cassette. Absence of gene expression was confirmed by Western blot analysis of embyronic fibrobasts derived from homozygous mutants. (J:83753)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bin1 Mutation:  12 strains or lines available
Original:  J:83753 Muller AJ, et al., Targeted disruption of the murine Bin1/Amphiphysin II gene does not disable endocytosis but results in embryonic cardiomyopathy with aberrant myofibril formation. Mol Cell Biol. 2003 Jun;23(12):4295-306
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory