Tg(Rho-GUCA1B)1Jnc
Transgene Detail

Summary

• Symbol: Tg(Rho-GUCA1B)1Jnc
• Name: transgene insertion 1, Jeannie Chen
• MGI ID: MGI:2664161
• Transgene: Tg(Rho-GUCA1B)1Jnc Location: unknown
• Alliance: Tg(Rho-GUCA1B)1Jnc page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Rho-GUCA1B)1Jnc expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  cattle	GUCA1B (286851)

• Mutation details: A 0.7 kb cDNA fragment encoding the bovine GUCA1B was adjoined to a 4.4 kb murine rhodopsin promoter and a polyadenylation signal from the murine Prm1 locus. Expression of the bovine GUCA1B was approximately 2-fold higher than that of the endogenous murine Guca1B. The pattern of retinal expression was shown to be similar to that of murine Guca1b by Indirect immunofluorescent labeling. (J:83914)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:83914 Mendez A, et al., Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors. Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9948-53
• All: 2 reference(s)