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Fasntm1Schi
Targeted Allele Detail
Nomenclature
Symbol: Fasntm1Schi
Name: fatty acid synthase; targeted mutation 1, Subrahmanyam S Chirala
MGI ID: MGI:2664027
Synonyms: Fasn-, Fasntm1sc
Gene: Fasn  Location: Chr11:120805846-120824547 bp, - strand  Genetic Position: Chr11, 84.56 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83624
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment encompassing exons 11 through 18 was replaced with an hprt cassette inserted by homologous recombination. The deleted region encoded the acetyl and malonyl-transacylases and dehydratase domains. (J:83624)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fasn Mutation:  52 strains or lines available
References
Original:  J:83624 Chirala SS, et al., Fatty acid synthesis is essential in embryonic development: Fatty acid synthase null mutants and most of the heterozygotes die in utero. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6358-63
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory