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Transgene Detail
Symbol: Tg(NES-TVA)J12Ech
Name: transgene insertion J12, Eric C Holland
MGI ID: MGI:2663944
Synonyms: Nestin:Tva, Ntv-1, N-tva, Ntv-a, Tg(NES-TVA)12Hev
Transgene: Tg(NES-TVA)J12Ech  Location: unknown  
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsThe transgene expresses TVA, the receptor for avian retrovirus ALV, subgroup A (ALV-A), from a quail cDNA under control of a modified human nestin promoter that includes the second-intron enhancer - which in adult mice directs expression specifically in early glial progenitor cells - and the herpes simplex virus thymidine kinase (HSV-TK) promoter. Cells presenting this receptor can be infected by replication-competent ALV splice acceptor (RCAS) vectors, permitting cell type specific expression of vector-borne genes. (J:52161)
View phenotypes and curated references for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Glial progenitor cells in transgenic mice are specifically susceptible to infection by viral vectors.
Original:  J:52161 Holland EC, et al., A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev. 1998 Dec 1;12(23):3675-85
All:  68 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
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