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Slc5a3tm1Gtb
Targeted Allele Detail
Summary
Symbol: Slc5a3tm1Gtb
Name: solute carrier family 5 (inositol transporters), member 3; targeted mutation 1, Gerard T Berry
MGI ID: MGI:2663787
Synonyms: SMIT1-/-
Gene: Slc5a3  Location: Chr16:91855210-91884361 bp, + strand  Genetic Position: Chr16, 53.44 cM
Alliance: Slc5a3tm1Gtb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83591
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire gene coding region was replaced with a PGK-neo cassette via homologous recombination. Northern blot analysis of fetal and placental mRNA confirmed the absence of gene expression in homozygous mutant animals. (J:83591)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc5a3 Mutation:  24 strains or lines available
References
Original:  J:83591 Berry GT, et al., Loss of murine Na+/myo-inositol cotransporter leads to brain myo-inositol depletion and central apnea. J Biol Chem. 2003 May 16;278(20):18297-302
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory