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Agrntm4Jrs
Targeted Allele Detail
Nomenclature
Symbol: Agrntm4Jrs
Name: agrin; targeted mutation 4, Joshua R Sanes
MGI ID: MGI:2663725
Synonyms: AGD-, agrin-, AgrnDel, Agrntm1Klee
Gene: Agrn  Location: Chr4:156165290-156197488 bp, - strand  Genetic Position: Chr4, 88.55 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83827
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe endogenous locus was disrupted by the removal of a genomic fragment extending from within exon 6 into intron 33 (~9 kb). The deletion removed sequence encoding both the neural and non-neural isoforms. Protein was undetected in homozygous mutant mice by immunohistochemical and Western blot analyses. (J:83827)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Agrn Mutation:  43 strains or lines available
References
Original:  J:83827 Lin W, et al., Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse. Nature. 2001 Apr 26;410(6832):1057-64
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory