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Targeted Allele Detail
Symbol: Notch2tm2Hhi
Name: notch 2; targeted mutation 2, Hisamaru Hirai
MGI ID: MGI:2663711
Synonyms: Notch2-
Gene: Notch2  Location: Chr3:98013538-98150367 bp, + strand  Genetic Position: Chr3, 42.42 cM
Germline Transmission:  Earliest citation of germline transmission: J:83476
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsFlanking loxP sites and a PGK-neo cassette were introduced to the exons encoding the transmembrane domains. These exons were subsequently deleted by transient expression of cre recombinase in correctly targeted ES cells. Absence of gene expression in homozygous mutant embryos was confirmed by Western blot analysis. (J:83476)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Notch2 Mutation:  9 strains or lines available
Original:  J:83476 Saito T, et al., Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity. 2003 May;18(5):675-85
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory