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Rac1tm1.1Djk
Targeted Allele Detail
Nomenclature
Symbol: Rac1tm1.1Djk
Name: Rac family small GTPase 1; targeted mutation 1.1, David J Kwiatkowski
MGI ID: MGI:2663669
Synonyms: Rac1-, Rac1tm1.1Glog
Gene: Rac1  Location: Chr5:143505481-143528031 bp, - strand  Genetic Position: Chr5, 82.22 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83457
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 1 and a loxP site flanked neomycin resistance gene cassette into intron 1. The neo cassette was removed and exon 1 deleted through subsequent cre-mediated recombination, creating a null allele. (J:83457)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rac1 Mutation:  11 strains or lines available
References
Original:  J:83457 Glogauer M, et al., Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions. J Immunol. 2003 Jun 1;170(11):5652-7
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory