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Tg(Plp1-cre/ERT2)1Ueli
Transgene Detail
Nomenclature
Symbol: Tg(Plp1-cre/ERT2)1Ueli
Name: transgene insertion 1, Ueli Suter
MGI ID: MGI:2663093
Synonyms: PLP-CreERT2, PLP/Cre-ERT2, Tg(Plp1-cre/ESR1)1Ueli
Transgene: Tg(Plp1-cre/ERT2)1Ueli  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsThe transgene consists of a mouse Plp promoter region (exons 1 and 2) and a cre-ESR1 cassette. The human ESR1 sequence is mutated at G400V, M543A, and L540A in the ligand binding domain to allow activation by 4-hydroxytamoxifen (OHT) and ICI 182,780. 15 kb of mouse Plp promoter sequences drive transgene expression in oligodenrocytes and Schwann cells. (J:83361)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Plp1     Summary of all recombinase alleles driven by Plp1. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:83361 Leone DP, et al., Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells. Mol Cell Neurosci. 2003 Apr;22(4):430-40
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory