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Mylktm1Dmw
Targeted Allele Detail
Nomenclature
Symbol: Mylktm1Dmw
Name: myosin, light polypeptide kinase; targeted mutation 1, D Martin Watterson
MGI ID: MGI:2662927
Synonyms: MLCK-, nmmlck-
Gene: Mylk  Location: Chr16:34745210-35002420 bp, + strand  Genetic Position: Chr16, 24.49 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83394
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsSequence specific for the endothelial cell isoform (MLCK210) was disrupted by the insertion of a neo cassette into exon 8, leaving sequence encoding the smooth muscle isoform (MLCK108) intact. Western blot analysis of homozygous mutant mice demonstrated that while MLCK210 protein is undetected, the level of MLCK108 protein is similar to that of wild-type. (J:83394)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mylk Mutation:  5 strains or lines available
References
Original:  J:83394 Wainwright MS, et al., Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment. Proc Natl Acad Sci U S A. 2003 May 13;100(10):6233-8
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory