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Ncf1m1J
Spontaneous Allele Detail
Nomenclature
Symbol: Ncf1m1J
Name: neutrophil cytosolic factor 1; mutation 1, Jackson
MGI ID: MGI:2661962
Synonyms: Ncf1*, p47-, p47phox, p47phox-`, rs230824082
Gene: Ncf1  Location: Chr5:134220053-134229625 bp, - strand  Genetic Position: Chr5, 74.47 cM
Ncf1m1J/ Ncf1m1J mice carrying the H2q haplotype develop enhanced collagen II autoimmunity and chronic collagen II induced arthritis

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  B6.Cg-Dock7m +/+ Leprdb/J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsThe mutation is an A to C transversion at -2 position at the 5' end of exon 8 of the Ncf1 gene, resulting in aberrant splicing of the Ncf1 transcript. Immunoblotting detected no intact NCF1 protein in cells from these mice. (J:83428)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ncf1 Mutation:  27 strains or lines available
References
Original:  J:83428 Huang CK, et al., P47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+. J Leukoc Biol. 2000 Feb;67(2):210-5
All:  93 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory