Aire^tm1Doi
Targeted Allele Detail

Summary

• Symbol: Aire^tm1Doi
• Name: autoimmune regulator; targeted mutation 1, Christophe Benoist and Diane Mathis
• MGI ID: MGI:2661909
• Gene: Aire Location: Chr10:77865856-77879444 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Aire^tm1Doi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83422
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 2 was flanked by a single loxP site in intron 1 and a floxed neo cassette in intron 2. (J:83422)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aire Mutation: 52 strains or lines available

References

• Original: J:83422 Anderson MS, et al., Projection of an immunological self shadow within the thymus by the aire protein. Science. 2002 Nov 15;298(5597):1395-401
• All: 3 reference(s)