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Targeted Allele Detail
Symbol: Miftm1Mky
Name: macrophage migration inhibitory factor (glycosylation-inhibiting factor); targeted mutation 1, Toshifumi Mikayama
MGI ID: MGI:2661491
Synonyms: GIF-, MIF-
Gene: Mif  Location: Chr10:75859353-75860240 bp, - strand  Genetic Position: Chr10, 38.59 cM, cytoband C1
Germline Transmission:  Earliest citation of germline transmission: J:75496
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of a 201 bp region spanning parts of exon 1 and intron 1 with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of brain extracts. (J:75496)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mif Mutation:  14 strains or lines available
Original:  J:75496 Honma N, et al., Deficiency of the macrophage migration inhibitory factor gene has no significant effect on endotoxaemia. Immunology. 2000 May;100(1):84-90
All:  16 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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