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Rtn4tm3.1Matl
Targeted Allele Detail
Summary
Symbol: Rtn4tm3.1Matl
Name: reticulon 4; targeted mutation 3.1, Marc Tessier-Lavigne
MGI ID: MGI:2661204
Gene: Rtn4  Location: Chr11:29642947-29694331 bp, + strand  Genetic Position: Chr11, 16.79 cM
Alliance: Rtn4tm3.1Matl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83192
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe genomic fragment flanked by a single loxP site in intron 1 and a floxed neo cassette that had replaced exon 5 was excised from Rtn4tm3Matl via cre mediated recombination in the germline. The IRES-GFPLacZ cassette remained in exon 1. RT-PCR confirmed gene inactivation for all three isoforms. (J:83192, J:151085)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rtn4 Mutation:  130 strains or lines available
References
Original:  J:83192 Zheng B, et al., Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron. 2003 Apr 24;38(2):213-24
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory