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Rtn4tm3Matl
Targeted Allele Detail
Summary
Symbol: Rtn4tm3Matl
Name: reticulon 4; targeted mutation 3, Marc Tessier-Lavigne
MGI ID: MGI:2661203
Synonyms: Nogo N/C double
Gene: Rtn4  Location: Chr11:29642947-29694331 bp, + strand  Genetic Position: Chr11, 16.79 cM
Alliance: Rtn4tm3Matl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83192
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Conditional ready, Hypomorph, Reporter)
Mutation:    Insertion
 
Mutation detailsThe amino and carboxy terminals were targeted in cis to generate an allele from which no protein is produced. The amino terminal was disrupted by the insertion of IRES-GFPLacZ-loxP and an frt-flanked hprt cassette. A floxed neo cassette disrupted the carboxy terminal exon encoding the first transmembrane domain, common to all isoforms. (J:83192, J:151085)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rtn4 Mutation:  130 strains or lines available
References
Original:  J:83192 Zheng B, et al., Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron. 2003 Apr 24;38(2):213-24
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory