Ssta3^HIII
QTL Variant Detail

Summary

• QTL variant: Ssta3^HIII
• Name: susceptibility to Salmonella typhimurium antigens 3; HIII
• MGI ID: MGI:2661154
• QTL: Ssta3 Location: unknown Genetic Position: Chr6, cM position of peak correlated region/allele: 35.94 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: HIII

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:83227

Linkage analysis was performed on the highest and lowest antibody titer animals from an (HIII x LIII)F2 cross to identify QTLs associated with susceptibility to infection by Salmonella typhimurium. The animals were intraperitonally injected with S.typhi antigens and measured for antibody titers. HIII is a high antibody responder strain whereas LIII is a low antibody responder strain. Four loci were identified with significant linkage to susceptibility to Salmonella infection. Ssta1 and Ssta2 mapped to mouse Chromosome 1 at 34.8 cM (D1Mit303) and 95.8 cM (D1Mit356), respectively. Ssta1 is linked to anti-flagellar antibody production and Ssta2 is linked to both anti-flagellar antibody production and autosomal antigen activity. Ssta3 maps to 35 cM on mouse Chromosome 6 in linkage to D6Mit128 and D6Mit6. Ssta3 is associated with anti-flagellar antibody production. Ssta4 maps to 37 cM on mouse Chromosome 11 at D11Mit5 and is also associated with anti-flagellar antibody production.

References

• Original: J:83227 Trezena AG, et al., Co-localization of quantitative trait loci regulating resistance to Salmonella typhimurium infection and specific antibody production phenotypes. Microbes Infect. 2002 Nov;4(14):1409-15
• All: 1 reference(s)