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Itgaltm1Bll
Targeted Allele Detail
Nomenclature
Symbol: Itgaltm1Bll
Name: integrin alpha L; targeted mutation 1, Christie M Ballantyne
MGI ID: MGI:2661083
Synonyms: Cd11a(-), CD11alpha KO, LFA-1-
Gene: Itgal  Location: Chr7:127296260-127335138 bp, + strand  Genetic Position: Chr7, 69.44 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83226
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 and 2 were replaced with a neomycin selection casssette inserted by homologous recombination. (J:83226)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Itgal Mutation:  38 strains or lines available
References
Original:  J:83226 Ding ZM, et al., Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. J Immunol. 1999 Nov 1;163(9):5029-38
All:  40 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory