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Targeted Allele Detail
Symbol: Tial1tm1Mst
Name: Tia1 cytotoxic granule-associated RNA binding protein-like 1; targeted mutation 1, Michel Streuli
MGI ID: MGI:2660803
Synonyms: tiar-
Gene: Tial1  Location: Chr7:128439777-128461717 bp, - strand  Genetic Position: Chr7, 70.2 cM, cytoband F4
Lack of germ cells in Tial1tm1Mst/Tial1tm1Mst mouse testes and ovaries

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:46239
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 5' portion of exon 6 was replaced with a neo cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of extracts from homozygous mutant ES cells. (J:46239)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tial1 Mutation:  13 strains or lines available
Original:  J:46239 Beck ARP, et al., RNA-binding protein TIAR is essential for primordial germ cell development. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2331-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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