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Targeted Allele Detail
Symbol: Hpgdtm1Bhk
Name: hydroxyprostaglandin dehydrogenase 15 (NAD); targeted mutation 1, Beverly H Koller
MGI ID: MGI:2657242
Synonyms: Pgdh-
Gene: Hpgd  Location: Chr8:56294585-56321043 bp, + strand  Genetic Position: Chr8, 29.7 cM, cytoband B3.2
Germline Transmission:  Earliest citation of germline transmission: J:74466
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of sequences corresponding to amino acids 167-266 of the human protein with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot analysis of lung and liver RNA. (J:74466)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hpgd Mutation:  3 strains or lines available
Phenotypic Similarity to Human Syndrome: Patent Ductus Arteriosus in homozygous mice (J:74466)
Original:  J:74466 Coggins KG, et al., Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus. Nat Med. 2002 Feb;8(2):91-2
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory