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Brs3tm1Jfb
Targeted Allele Detail
Nomenclature
Symbol: Brs3tm1Jfb
Name: bombesin-like receptor 3; targeted mutation 1, James F Battey
MGI ID: MGI:2657217
Synonyms: BRS-3 KO
Gene: Brs3  Location: ChrX:57043074-57048758 bp, + strand  Genetic Position: ChrX, 30.78 cM, cytoband A7.1-A7.2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:134021
Parent Cell Line:  GSI-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 has been replaced with a neomycin resistance cassette. No transcript from the disrupted gene was detected in mRNA from brains of homozygous mutant mice by reverse transcription followed by PCR analysis (RT-PCR). (J:134021)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Brs3 Mutation:  8 strains or lines available
References
Original:  J:134021 Ladenheim EE, et al., Factors contributing to obesity in bombesin receptor subtype-3-deficient mice. Endocrinology. 2008 Mar;149(3):971-8
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory