Ptgds^tm1Ohy
Targeted Allele Detail

Summary

• Symbol: Ptgds^tm1Ohy
• Name: prostaglandin D2 synthase (brain); targeted mutation 1, Osamu Hayaishi
• MGI ID: MGI:2657199
• Synonyms: L-Pgds^-, PGDS^-
• Gene: Ptgds Location: Chr2:25356721-25360058 bp, - strand Genetic Position: Chr2, 17.28 cM
• Alliance: Ptgds^tm1Ohy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52290
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exons 2-5 with a neomycin resistance cassette via homologous recombination. Absence of gene expression was confirmed by Northern blot analysis and enzyme activity was undetectable in brains from homozygous mutant animals. (J:52290)

Expression

In Mice Carrying this Mutation:	2 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptgds Mutation: 15 strains or lines available

References

• Original: J:52290 Eguchi N, et al., Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice. Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):726-30
• All: 28 reference(s)