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Kif5atm2Gsn
Targeted Allele Detail
Nomenclature
Symbol: Kif5atm2Gsn
Name: kinesin family member 5A; targeted mutation 2, Lawrence S B Goldstein
MGI ID: MGI:2656904
Synonyms: KIF5Aflox
Gene: Kif5a  Location: Chr10:127225696-127263348 bp, - strand  Genetic Position: Chr10, 74.5 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82911
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsTwo coding exons were flanked with a floxed PGK-neo cassette and single loxP site via homologous recombination. The PGK-neo cassette was removed by transient expression of cre recombinase in correctly targeted ES cells. Resulting mutant animals carry loxP sites flanking 2 coding exons. (J:82911)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kif5a Mutation:  27 strains or lines available
References
Original:  J:82911 Xia CH, et al., Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A. J Cell Biol. 2003 Apr 14;161(1):55-66
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory