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Targeted Allele Detail
Symbol: Kif5atm1Gsn
Name: kinesin family member 5A; targeted mutation 1, Lawrence S B Goldstein
MGI ID: MGI:2656900
Synonyms: KIF5Anull, Kinesin-1A-
Gene: Kif5a  Location: Chr10:127225696-127263348 bp, - strand  Genetic Position: Chr10, 74.5 cM
Germline Transmission:  Earliest citation of germline transmission: J:82911
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsTwo coding exons were flanked with a floxed PGK-neo cassette and single loxP site via homologous recombination. The 2 exons and PGK-neo cassette were removed by transient expression of cre recombinase in correctly targeted ES cells. Western blot analysis of brain extracts from homozygous mutant embryos confirmed the absence of gene expression. (J:82911)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kif5a Mutation:  27 strains or lines available
Original:  J:82911 Xia CH, et al., Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A. J Cell Biol. 2003 Apr 14;161(1):55-66
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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