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Targeted Allele Detail
Symbol: Faptm2Schn
Name: fibroblast activation protein; targeted mutation 2, Andreas Schnapp
MGI ID: MGI:2656736
Synonyms: Fap- lacZ
Gene: Fap  Location: Chr2:62331280-62404365 bp, - strand  Genetic Position: Chr2, 35.85 cM
Germline Transmission:  Earliest citation of germline transmission: J:74135
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of a portion of exons 4 and 5 with a lacZ-neo cassette via homologous recombination. The gene targeting event results in an in-frame fusion of exon 4 with the lacZ gene. Protein extracts from homozygous mutant embryos did not exhibit enzyme activity. (J:74135)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fap Mutation:  37 strains or lines available
Original:  J:74135 Niedermeyer J, et al., Expression of the fibroblast activation protein during mouse embryo development. Int J Dev Biol. 2001 Apr;45(2):445-7
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory