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Targeted Allele Detail
Symbol: Hoxb13tm3Mrc
Name: homeobox B13; targeted mutation 3, Mario R Capecchi
MGI ID: MGI:2656726
Synonyms: Hoxb13lacZneo
Gene: Hoxb13  Location: Chr11:96194316-96196610 bp, + strand  Genetic Position: Chr11, 59.63 cM
Germline Transmission:  Earliest citation of germline transmission: J:82849
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA lacZ gene was inserted into exon 2 at codon 33, disrupting the homeodomain. The targeting vector included a floxed neo cassette immediately downstream of lacZ. Subsequent in vivo excision of the floxed neo cassette resulted in Hoxb13tm1Mrc. (J:82849)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxb13 Mutation:  7 strains or lines available
Original:  J:82849 Economides KD, et al., Hoxb13 mutations cause overgrowth of caudal spinal cord and tail vertebrae. Dev Biol. 2003 Apr 15;256(2):317-30
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory