Drd2^tm1Yyw
Targeted Allele Detail

Summary

• Symbol: Drd2^tm1Yyw
• Name: dopamine receptor D2; targeted mutation 1, Yanyan Wang
• MGI ID: MGI:2656648
• Synonyms: D2L-
• Gene: Drd2 Location: Chr9:49251927-49319477 bp, + strand Genetic Position: Chr9, 26.72 cM
• Alliance: Drd2^tm1Yyw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65770
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A long isoform specific allele was generated by replacing an 87 bp fragment containing exon 6 with a floxed neomycin selection cassette. RT-PCR analysis and radiolabeled binding assays showed an absence of the long isoform in homozygous mutant mice. Both mRNA and protein levels of the short isoform were increased and equivalent to the level of total Drd2 mRNA and protein in homozygous mice. (J:65770)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Drd2 Mutation: 70 strains or lines available

References

• Original: J:65770 Wang Y, et al., Dopamine D2 long receptor-deficient mice display alterations in striatum-dependent functions. J Neurosci. 2000 Nov 15;20(22):8305-14
• All: 11 reference(s)