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Targeted Allele Detail
Symbol: Amottm1Bhr
Name: angiomotin; targeted mutation 1, Richard R Behringer
MGI ID: MGI:2656627
Synonyms: Xamot
Gene: Amot  Location: ChrX:145446425-145505181 bp, - strand  Genetic Position: ChrX, 66.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:82844
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of the splice acceptor site of the second exon with a PGK-neo cassette via homologous recombination. RT-PCR sequence analysis showed the mutant allele contains a frameshift and premature stop codon, therefore no functional protein product should be translated. (J:82844)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Amot Mutation:  0 strains or lines available
Original:  J:82844 Shimono A, et al., Angiomotin Regulates Visceral Endoderm Movements during Mouse Embryogenesis. Curr Biol. 2003 Apr 1;13(7):613-7
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory