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QTL Variant Detail
QTL variant: Pgia22BALB/cCrl
Name: proteoglycan induced arthritis 22; BALB/cCrl
MGI ID: MGI:2656605
QTL: Pgia22  Location: Chr8:102486208-116025457 bp  Genetic Position: Chr8, Syntenic
Strain of Specimen:  BALB/cCrl
Allele Type:    QTL

Mapping and Phenotype information for this QTL, its variants and associated markers


135 SSLP markers were screened in a set of 939 (BALB/cCrl x DBA/1J)F2 intercross animals to identify QTLs associated with collagen-induced arthritis (CIA) and proteoglycan-induced arthritis (PGIA). Parental strain BALB/cCrl is CIA-resistant and PGIA-susceptible while parental strain DBA/1J is CIA-susceptible and PGIA-resistant.

A major locus was identified on mouse Chromosome 17 in linkage to both CIA (LOD=21) and PGIA (LOD=6). This locus, Pgia17, has been previously identified and maps to proximal Chromosome 17.

Pgia22, a novel locus associated with PGIA, mapped to an interval spanning 47cM - 59cM on mouse Chromosome 8 flanked by markers D8Mit242 and D8Mit320. Pgia22 is linked to IL-1 production (LOD=3.1)

A novel locus associated with CIA, Cia16, maps to mouse Chromosome 8 at approximately 28 cM with peak marker D8Mit46. Cia16 is linked to soluble CD44 production (LOD=3.3).

(*Authors list D8Mit46 as the marker in close linkage with Cia16, but this MIT marker has been re-named D9Mit1000.)

Original:  J:82018 Adarichev VA, et al., Combined autoimmune models of arthritis reveal shared and independent qualitative (binary) and quantitative trait loci. J Immunol. 2003 Mar 1;170(5):2283-92
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
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