Atr^tm2Bal
Targeted Allele Detail

Summary

• Symbol: Atr^tm2Bal
• Name: ataxia telangiectasia and Rad3 related; targeted mutation 2, David Baltimore
• MGI ID: MGI:2656567
• Synonyms: ATR^flox
• Gene: Atr Location: Chr9:95739650-95833834 bp, + strand Genetic Position: Chr9, 50.27 cM, cytoband E4
• Alliance: Atr^tm2Bal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83042
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted flanking exons encoding essential regions of the kinase domain. An adjacent frt-flanked neomycin and thymidine kinase cassette was removed by Flp-mediated recombination in ES cells prior to the production of mice. (J:83042)

Expression

In Structures Affected by this Mutation:

24 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atr Mutation: 132 strains or lines available

References

• Original: J:83042 Brown EJ, et al., Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev. 2003 Mar 1;17(5):615-28
• All: 26 reference(s)