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Atrtm2Bal
Targeted Allele Detail
Nomenclature
Symbol: Atrtm2Bal
Name: ataxia telangiectasia and Rad3 related; targeted mutation 2, David Baltimore
MGI ID: MGI:2656567
Synonyms: ATRflox
Gene: Atr  Location: Chr9:95857597-95951781 bp, + strand  Genetic Position: Chr9, 50.27 cM, cytoband E4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83042
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites were inserted flanking exons encoding essential regions of the kinase domain. An adjacent frt-flanked neomycin and thymidine kinase cassette was removed by Flp-mediated recombination in ES cells prior to the production of mice. (J:83042)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 25 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atr Mutation:  86 strains or lines available
References
Original:  J:83042 Brown EJ, et al., Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev. 2003 Mar 1;17(5):615-28
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory