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Targeted Allele Detail
Symbol: Il9tm1Anjm
Name: interleukin 9; targeted mutation 1, Andrew NJ McKenzie
MGI ID: MGI:2656470
Synonyms: il9-, IL-9-
Gene: Il9  Location: Chr13:56479277-56482246 bp, - strand  Genetic Position: Chr13, 30.06 cM
Germline Transmission:  Earliest citation of germline transmission: J:82881
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 4 was disrupted by homologous recombination of a targeting vector containing stop codons in all three reading frames and a neomycin selection cassette that replaces amino acids 54 through 59. Transcript was undetected by RT-PCR analysis of activated lymphocytes obtained from homozygous mutant mice. ELISA indicated the absence of protein in splenocyte cultures derived from homozygotes. (J:82881)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Il9 Mutation:  13 strains or lines available
Original:  J:82881 Townsend JM, et al., IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development. Immunity. 2000 Oct;13(4):573-83
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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