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Targeted Allele Detail
Symbol: Iapptm1Sgm
Name: islet amyloid polypeptide; targeted mutation 1, Samuel Gebre-Medhin
MGI ID: MGI:2656235
Synonyms: Amylin -, IAPP-
Gene: Iapp  Location: Chr6:142298423-142303961 bp, + strand  Genetic Position: Chr6, 73.81 cM
Germline Transmission:  Earliest citation of germline transmission: J:50042
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exon 3 with a neomycin resistance cassette via homologous recombination. Absence of gene expression was confirmed by immunohistochemical analysis of islet cells from homozygous mutant animals. (J:50042)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Iapp Mutation:  7 strains or lines available
Original:  J:50042 Gebre-Medhin S, et al., Increased insulin secretion and glucose tolerance in mice lacking islet amyloid polypeptide (amylin). Biochem Biophys Res Commun. 1998 Sep 18;250(2):271-7
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory