About   Help   FAQ
Iapptm1Sgm
Targeted Allele Detail
Nomenclature
Symbol: Iapptm1Sgm
Name: islet amyloid polypeptide; targeted mutation 1, Samuel Gebre-Medhin
MGI ID: MGI:2656235
Synonyms: Amylin -, IAPP-
Gene: Iapp  Location: Chr6:142298423-142303961 bp, + strand  Genetic Position: Chr6, 73.81 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50042
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exon 3 with a neomycin resistance cassette via homologous recombination. Absence of gene expression was confirmed by immunohistochemical analysis of islet cells from homozygous mutant animals. (J:50042)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Iapp Mutation:  7 strains or lines available
References
Original:  J:50042 Gebre-Medhin S, et al., Increased insulin secretion and glucose tolerance in mice lacking islet amyloid polypeptide (amylin). Biochem Biophys Res Commun. 1998 Sep 18;250(2):271-7
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/08/2017
MGI 6.10
The Jackson Laboratory