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Targeted Allele Detail
Symbol: Igbp1tm1Imku
Name: immunoglobulin (CD79A) binding protein 1; targeted mutation 1, Nobuo Sakaguchi
MGI ID: MGI:2656093
Synonyms: alpha4flox
Gene: Igbp1  Location: ChrX:100494291-100516125 bp, + strand  Genetic Position: ChrX, 43.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:74619
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette flanked by two loxP sites was introduced downstream of exon 2, and an additional loxP site was inserted upstream of exon 1. (J:74619)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igbp1 Mutation:  8 strains or lines available
Original:  J:74619 Inui S, et al., BCR signal through alpha 4 is involved in S6 kinase activation and required for B cell maturation including isotype switching and V region somatic hypermutation. Int Immunol. 2002 Feb;14(2):177-87
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory