Igbp1^tm1Imku
Targeted Allele Detail

Summary

• Symbol: Igbp1^tm1Imku
• Name: immunoglobulin (CD79A) binding protein 1; targeted mutation 1, Nobuo Sakaguchi
• MGI ID: MGI:2656093
• Synonyms: alpha4flox
• Gene: Igbp1 Location: ChrX:99537897-99559731 bp, + strand Genetic Position: ChrX, 43.72 cM
• Alliance: Igbp1^tm1Imku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74619
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette flanked by two loxP sites was introduced downstream of exon 2, and an additional loxP site was inserted upstream of exon 1. (J:74619)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igbp1 Mutation: 8 strains or lines available

References

• Original: J:74619 Inui S, et al., BCR signal through alpha 4 is involved in S6 kinase activation and required for B cell maturation including isotype switching and V region somatic hypermutation. Int Immunol. 2002 Feb;14(2):177-87
• All: 4 reference(s)