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Casp8tm1Raz
Targeted Allele Detail
Nomenclature
Symbol: Casp8tm1Raz
Name: caspase 8; targeted mutation 1, Razqallah Hakem
MGI ID: MGI:2655730
Synonyms: Casp8fl, casp8fl4-3
Gene: Casp8  Location: Chr1:58795374-58847503 bp, + strand  Genetic Position: Chr1, 29.19 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82759
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 3 and a floxed neo-tk cassette was inserted downstream of exon 4. The neo-tk cassette was removed by transient expression of cre recombinase in correctly targeted ES cells. Resulting mutant animals carry loxP-flanked exons 3-4. (J:82759)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Casp8 Mutation:  26 strains or lines available
References
Original:  J:82759 Salmena L, et al., Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes Dev. 2003 Apr 1;17(7):883-95
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/05/2018
MGI 6.12
The Jackson Laboratory