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Targeted Allele Detail
Symbol: Rpgrip1tm1Tili
Name: retinitis pigmentosa GTPase regulator interacting protein 1; targeted mutation 1, Tiansen Li
MGI ID: MGI:2655714
Synonyms: RPGRIP-
Gene: Rpgrip1  Location: Chr14:52110704-52163546 bp, + strand  Genetic Position: Chr14, 26.81 cM
Ultrastructural examination of Rpgrip1tm1Tili/Rpgrip1tm1Tili mouse photoreceptors

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:82755
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Modified isoform(s), Null/knockout)
Mutation:    Insertion
Mutation detailsThe gene was disrupted by insertion of a large cassette containing 3 duplicated exons and a neomycin resistance gene. RT-PCR and sequence analysis of mRNA from homozygous mutant animals detected a premature stop codon. Absence of gene expression in homozygous animals was confirmed by Western blot analysis. (J:82755, J:243745)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rpgrip1 Mutation:  14 strains or lines available
Original:  J:82755 Zhao Y, et al., The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: subserving RPGR function and participating in disk morphogenesis. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3965-70
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory