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Targeted Allele Detail
Symbol: Hbegftm1.1Mek
Name: heparin-binding EGF-like growth factor; targeted mutation 1.1, Eisuke Mekada
MGI ID: MGI:2655703
Synonyms: HBdel, Hbegf-
Gene: Hbegf  Location: Chr18:36637980-36648858 bp, - strand  Genetic Position: Chr18, 19.46 cM
Alliance: Hbegftm1.1Mek page
Germline Transmission:  Earliest citation of germline transmission: J:82728
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe loxP-flanked, wild-type Hbegf cDNA was excised from Hbegftm1Mek via Cre-mediated recombination in progeny of a cross between mice with the floxed allele and mice bearing a ubiquitously expressed cre transgene. The bacterial beta-galactosidase gene (lacZ) and the Pgk-neo cassette remain in place of most of exon 1 through exon 3 and most of the third intron of the native gene. Expression of lacZ is driven by the endogenous promoter; the beta-galactosidase protein is localized to the nucleus. (J:82728)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 41 assay results
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Hbegf Mutation:  23 strains or lines available
Original:  J:82728 Iwamoto R, et al., Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function. Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3221-6
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory