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Hbegftm1Mek
Targeted Allele Detail
Nomenclature
Symbol: Hbegftm1Mek
Name: heparin-binding EGF-like growth factor; targeted mutation 1, Eisuke Mekada
MGI ID: MGI:2655700
Synonyms: Dtrtm1(lox), Hbegflox, HBlox
Gene: Hbegf  Location: Chr18:36637980-36648858 bp, - strand  Genetic Position: Chr18, 19.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82728
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe wild-type mouse Hbegf cDNA, including the polyadenylation signal and flanked by loxP sites, is joined to the beginning of the first exon of the endogenous gene so that its expression is driven by the native promoter. The rest of exon 1 through exon 3 and most of intron 3 have been deleted. Downstream of the Hbegf cDNA are the bacterial beta-galactosidase gene (lacZ), with a polyadenylation signal and a nuclear targeting sequence, and the neomycin resistance gene driven by the phosphoglycerate kinase promoter, also with polyadenylation signal (Pgk-neo cassette), separated by a short segment from the middle of the third intron of the native gene. The lacZ gene is not expressed from this transgene. (J:82728)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hbegf Mutation:  23 strains or lines available
References
Original:  J:82728 Iwamoto R, et al., Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function. Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3221-6
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory