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Chrm1tm1Jwe
Targeted Allele Detail
Nomenclature
Symbol: Chrm1tm1Jwe
Name: cholinergic receptor, muscarinic 1, CNS; targeted mutation 1, Jurgen Wess
MGI ID: MGI:2655332
Synonyms: M1 -, M1R-, mAChR1-
Gene: Chrm1  Location: Chr19:8663789-8681567 bp, + strand  Genetic Position: Chr19, 5.44 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74588
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance cassette replaced a 0.28 kb genomic fragment that contained the translation start site and the region coding for the first 54 amino acids of the encoded protein. Immunoprecipitation studies demonstrated that no detectable protein was present in membranes prepared from hippocampus of homozygous mice. (J:74588)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chrm1 Mutation:  14 strains or lines available
References
Original:  J:74588 Fisahn A, et al., Muscarinic induction of hippocampal gamma oscillations requires coupling of the M1 receptor to two mixed cation currents. Neuron. 2002 Feb 14;33(4):615-24
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory