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Grin1tm2Slab
Targeted Allele Detail
Nomenclature
Symbol: Grin1tm2Slab
Name: glutamate receptor, ionotropic, NMDA1 (zeta 1); targeted mutation 2, Ralf Schoepfer
MGI ID: MGI:2655237
Synonyms: NR1-
Gene: Grin1  Location: Chr2:25291181-25319187 bp, - strand  Genetic Position: Chr2, 17.14 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82670
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe gene was disrupted by insertion of an 8 kb HSV-neo cassette into exon 1 upstream of the coding sequence. (J:82670)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Grin1 Mutation:  17 strains or lines available
References
Original:  J:82670 Rudhard Y, et al., Absence of Whisker-related pattern formation in mice with NMDA receptors lacking coincidence detection properties and calcium signaling. J Neurosci. 2003 Mar 15;23(6):2323-32
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory