H19^tm1Sriv
Targeted Allele Detail

Summary

• Symbol: H19^tm1Sriv
• Name: H19, imprinted maternally expressed transcript; targeted mutation 1, Madhulika Srivastava
• MGI ID: MGI:2655213
• Synonyms: H19^exIflox-neo
• Gene: H19 Location: Chr7:142129267-142131883 bp, - strand Genetic Position: Chr7, 87.97 cM
• Alliance: H19^tm1Sriv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82595
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector in which exon 1 was disrupted by a floxed neo cassette at +3 and a single loxP site at +713 was incorporated at the endogenous locus via homologous recombination. (J:82595)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H19 Mutation: 12 strains or lines available

References

• Original: J:82595 Srivastava M, et al., Imprint control element-mediated secondary methylation imprints at the Igf2/H19 locus. J Biol Chem. 2003 Feb 21;278(8):5977-83
• All: 2 reference(s)