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Tbx19tm1Jdr
Targeted Allele Detail
Nomenclature
Symbol: Tbx19tm1Jdr
Name: T-box 19; targeted mutation 1, Jacques Drouin
MGI ID: MGI:2655153
Synonyms: Tpit-
Gene: Tbx19  Location: Chr1:165137855-165160773 bp, - strand  Genetic Position: Chr1, 72.47 cM, cytoband H2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82562
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence encompassing a portion of exon 2 and all of exons 3 through 6 was replaced with a vector containing lacZ and neo. The deleted sequence encoded the majority of the T-box. Normal protein was undetected in homozygous mutant mice by immunohistochemical analysis. The lacZ expression pattern was similar to that of the endogenous gene. (J:82562)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbx19 Mutation:  6 strains or lines available
References
Original:  J:82562 Pulichino AM, et al., Tpit determines alternate fates during pituitary cell differentiation. Genes Dev. 2003 Mar 15;17(6):738-47
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/08/2018
MGI 6.12
The Jackson Laboratory