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Targeted Allele Detail
Symbol: Tnfaip6tm1Cful
Name: tumor necrosis factor alpha induced protein 6; targeted mutation 1, Csaba Fulop
MGI ID: MGI:2654926
Synonyms: Tnfip6-/-
Gene: Tnfaip6  Location: Chr2:51928125-51946693 bp, + strand  Genetic Position: Chr2, 29.98 cM
Germline Transmission:  Earliest citation of germline transmission: J:82539
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1 was disrupted by a neomycin selection cassette inserted via homologous recombination. Neither transcript nor protein was detected by RT-PCR and Western blot analysis of homozygous mutant embyronic fibroblasts, with and without Tnfa stimulation. (J:82539)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfaip6 Mutation:  14 strains or lines available
Original:  J:82539 Fulop C, et al., Impaired cumulus mucification and female sterility in tumor necrosis factor-induced protein-6 deficient mice. Development. 2003 May;130(10):2253-61
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory