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Tnfaip6tm1Cful
Targeted Allele Detail
Nomenclature
Symbol: Tnfaip6tm1Cful
Name: tumor necrosis factor alpha induced protein 6; targeted mutation 1, Csaba Fulop
MGI ID: MGI:2654926
Synonyms: Tnfip6-/-
Gene: Tnfaip6  Location: Chr2:52038009-52056686 bp, + strand  Genetic Position: Chr2, 29.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82539
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was disrupted by a neomycin selection cassette inserted via homologous recombination. Neither transcript nor protein was detected by RT-PCR and Western blot analysis of homozygous mutant embyronic fibroblasts, with and without Tnfa stimulation. (J:82539)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfaip6 Mutation:  10 strains or lines available
References
Original:  J:82539 Fulop C, et al., Impaired cumulus mucification and female sterility in tumor necrosis factor-induced protein-6 deficient mice. Development. 2003 May;130(10):2253-61
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory