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Targeted Allele Detail
Symbol: Thratm2Ven
Name: thyroid hormone receptor alpha; targeted mutation 2, Bjorn Vennstrom
MGI ID: MGI:2654864
Synonyms: alphatm2, TRalpha2 -
Gene: Thra  Location: Chr11:98740638-98769006 bp, + strand  Genetic Position: Chr11, 62.58 cM, cytoband D-E
Germline Transmission:  Earliest citation of germline transmission: J:72959
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsAn SV40 polyadenylation signal followed by a thymidine kinase/neomycin selection cassette was inserted into exon 10 in order to disrupt the alpha2 isoform, while maintaining the integrity of the alpha1 isoform. The last exon of the RevErbAalpha gene that overlaps with Thra exon 10 (TRalpha2-specific) on the opposite strand was unaffected. Northern blot analysis demonstrated that no detectable transcript for the alpha2 isoform was present in adult brain. The mutation leads to concomitant overexpression of alpha1 as a result of the structure of the 3' exons of the gene. (J:72959)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Thra Mutation:  21 strains or lines available
Original:  J:72959 Salto C, et al., Ablation of TRalpha2 and a Concomitant Overexpression of alpha1 Yields a Mixed Hypo- and Hyperthyroid Phenotype in Mice. Mol Endocrinol. 2001 Dec;15(12):2115-28
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory