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Scarb2tm1Psa
Targeted Allele Detail
Nomenclature
Symbol: Scarb2tm1Psa
Name: scavenger receptor class B, member 2; targeted mutation 1, Paul Saftig
MGI ID: MGI:2654430
Synonyms: LIMP-2-, LIMP2-, LIMP-2 KO
Gene: Scarb2  Location: Chr5:92441311-92505657 bp, - strand  Genetic Position: Chr5, 46.82 cM, cytoband E3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82474
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe gene was disrupted by insertion of a neo cassette into exon 8 via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR and Western blot analysis. (J:82474)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 17 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scarb2 Mutation:  36 strains or lines available
References
Original:  J:82474 Gamp AC, et al., LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice. Hum Mol Genet. 2003 Mar 15;12(6):631-46
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory