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Targeted Allele Detail
Symbol: Trp53bp1tm1Jc
Name: transformation related protein 53 binding protein 1; targeted mutation 1, Junjie Chen
MGI ID: MGI:2654201
Synonyms: 53BP1-, Trp53bp1delta
Gene: Trp53bp1  Location: Chr2:121193281-121271407 bp, - strand  Genetic Position: Chr2, 60.37 cM
Germline Transmission:  Earliest citation of germline transmission: J:82512
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of an exon containing nucleotides 3777 - 4048 with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis using an antibody directed against the N-terminal portion of the protein. (J:82512)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trp53bp1 Mutation:  69 strains or lines available
Original:  J:82512 Ward IM, et al., p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol Cell Biol. 2003 Apr;23(7):2556-63
All:  47 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory