About   Help   FAQ
MafOfl
Radiation induced Allele Detail
Nomenclature
Symbol: MafOfl
Name: avian musculoaponeurotic fibrosarcoma oncogene homolog; opaque flecks in lens
MGI ID: MGI:2654153
Synonyms: J-361
Gene: Maf  Location: Chr8:115682942-115707794 bp, - strand  Genetic Position: Chr8, 62.61 cM
Mutation
origin
Strain of Origin:  (C3H/HeEl x 102/El)F1
Mutation
description
Allele Type:    Radiation induced
Mutation:    Single point mutation
 
Mutation detailsThe mutation in this mouse was identified as a G to A transition resulting in the amino acid substitution R291Q in the basic region of the DNA binding domain. (J:82475)
Inheritance:    Semidominant
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Maf Mutation:  15 strains or lines available
References
Original:  J:82475 Lyon MF, et al., A dominant mutation within the DNA-binding domain of the bZIP transcription factor Maf causes murine cataract and results in selective alteration in DNA binding. Hum Mol Genet. 2003 Mar 15;12(6):585-94
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/12/2018
MGI 6.12
The Jackson Laboratory