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Rnf2tm1Mvl
Targeted Allele Detail
Nomenclature
Symbol: Rnf2tm1Mvl
Name: ring finger protein 2; targeted mutation 1, Maarten van Lohuizen
MGI ID: MGI:2653961
Synonyms: Rnf2-KO
Gene: Rnf2  Location: Chr1:151458004-151500955 bp, - strand  Genetic Position: Chr1, 64.15 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82399
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P/Ola
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsTwo exons encoding a major portion of the ring finger domain was replaced with a neomycin resistance cassette via homologous recombination. The mutant allele was confirmed by RT-PCR analysis of RNA from E9.5 homozygous mutant embryos. (J:82399)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rnf2 Mutation:  24 strains or lines available
References
Original:  J:82399 Voncken JW, et al., Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2468-73
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory