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Ppp1r3atm1Ptwc
Targeted Allele Detail
Nomenclature
Symbol: Ppp1r3atm1Ptwc
Name: protein phosphatase 1, regulatory subunit 3A; targeted mutation 1, Patricia T W Cohen
MGI ID: MGI:2653915
Synonyms: Gm
Gene: Ppp1r3a  Location: Chr6:14713977-14755274 bp, - strand  Genetic Position: Chr6, 6.31 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82422
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA single loxP site was left in place of exon 1 after the insertion and subsequent removal of a floxed neo cassette by homologous recombination and in vitro cre mediated excision. The deleted region encoded the start codon as well as the PP1 and glycogen-binding domains. Western blot analysis of homozygous mutant skeletal muscle indicated an absence of protein. (J:82422)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppp1r3a Mutation:  29 strains or lines available
References
Original:  J:82422 Delibegovic M, et al., Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance. Diabetes. 2003 Mar;52(3):596-604
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory