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Brca2tm2Hst
Targeted Allele Detail
Nomenclature
Symbol: Brca2tm2Hst
Name: breast cancer 2, early onset; targeted mutation 2, Paul Hasty
MGI ID: MGI:2653914
Synonyms: brca2lex2
Gene: Brca2  Location: Chr5:150522630-150570329 bp, + strand  Genetic Position: Chr5, 89.52 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82434
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsMost of exon 26 and all of exon 27 (coding nt 9265 through 9984) were replaced by a neomycin selection cassette inserted by homologous recombination. The deleted region included the RAD51-interacting domain. (J:49518, J:82434)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Brca2 Mutation:  63 strains or lines available
References
Original:  J:82434 Donoho G, et al., Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosomal instability, and reduced life span in mice. Genes Chromosomes Cancer. 2003 Apr;36(4):317-31
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/16/2017
MGI 6.09
The Jackson Laboratory