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Targeted Allele Detail
Symbol: Tnftm1Sek
Name: tumor necrosis factor; targeted mutation 1, Kenji Sekikawa
MGI ID: MGI:2653694
Synonyms: TNF-, TNF-alpha-, TNFalpha-, TNFalpha KO
Gene: Tnf  Location: Chr17:35418357-35420983 bp, - strand  Genetic Position: Chr17, 18.59 cM
Germline Transmission:  Earliest citation of germline transmission: J:44841
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAll of exon 3 and a portion of exon 4 were replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the DNA-binding domain (aa 84 through 174). (J:44841, J:92002)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tnf Mutation:  37 strains or lines available
Original:  J:44841 Taniguchi T, et al., Failure of germinal center formation and impairment of response to endotoxin in tumor necrosis factor alpha-deficient mice. Lab Invest. 1997 Dec;77(6):647-58
All:  64 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory