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Targeted Allele Detail
Symbol: Dspptm1Kul
Name: dentin sialophosphoprotein; targeted mutation 1, Ashok B Kulkarni
MGI ID: MGI:2653208
Synonyms: Dspp-
Gene: Dspp  Location: Chr5:104318578-104327993 bp, + strand  Genetic Position: Chr5, 50.59 cM
Tooth abnormalities in Dspptm1Kul/Dspptm1Kul mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:84378
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2 to 5 which span the entire coding region were replaced by a lacZ gene followed by a neomycin resistance gene. Lack of gene expression was established by RT-PCR and in situ hybridization. (J:84378)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dspp Mutation:  40 strains or lines available
Original:  J:84378 Sreenath T, et al., Dentin sialophosphoprotein knockout mouse teeth display widened predentin zone and develop defective dentin mineralization similar to human dentinogenesis imperfecta type III. J Biol Chem. 2003 Jul 4;278(27):24874-80
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory